DNA Athlete is a research project focused on human genetics, sports biology, and longevity, aiming to identify the genetic and molecular bases of aerobic endurance exercise, particularly in long-distance runners (marathoners) and physically active individuals of advanced age (90+).
What will be investigated?
Clinical and genetic profile
We will gather information on health, sports history, and lifestyle, in addition to analyzing the participants’ DNA.
Blood biomarkers
Based on blood samples, we will investigate proteins, signaling molecules, and other markers that help us understand the processes of adaptation to training.
Physical stress test
Participants will perform a treadmill test to measure cardiorespiratory capacity, metabolic thresholds, and VO₂ max—one of the key indicators of aerobic performance.
We want to understand how biological characteristics influence aerobic fitness and healthy aging!
Core questions
⇒ Are there genes, genetic variants, or biomarkers that favor the individual performance of long-distance runners (marathoners)?
⇒ Do individuals with a genetic predisposition favorable to aerobic exercise possess genes that protect against the cellular processes observed in aging?
Who can participate?
Marathon runners
The main group for the research project will consist of marathon runners of all ages and performance levels (ranging from elite athletes to dedicated amateurs). The inclusion criteria for the study are:
- Hold Brazilian nationality or a National Migration Registry (RNM) card (formerly the National Foreigner Registry – RNE)
- Be at least 18 years of age
- Have a successful track record in marathons and remain an active runner
- Possess a medical certificate clearing you to undergo a physical exertion test
Physically active long-lived individuals
Individuals over the age of 90 who still engage in physical activity or sports are very welcome to participate in the study, subject to the following inclusion criteria:
- Hold Brazilian nationality or a National Migration Registry (RNM) card (formerly the National Foreigner Registry – RNE)
- Be at least 90 years old
- Show no signs of functional or cognitive decline and be independent in basic activities of daily living
- Engage in regular physical activity or sports
Research project approved by the Research Ethics Committee of the Institute of Biosciences at the University of São Paulo (CAAE: 80479824.6.0000.5464).